First set of rational design principles for chaotropic membrane transporters

The challenge of internalizing impermeable molecules into cells persists in drug development, particularly concerning water-soluble bioactive compounds that cannot diffuse across the cell membrane. To overcome this problem, various artificial transporters, including polymers, lipids, and cationic penetrating peptides, have been engineered. https://phys.org/news/2024-07-rational-principles-chaotropic-membrane.html